Rate of decay and distribution volume of MB isoenzyme of creatine kinase, intravenously injected into the baboon.

نویسندگان

  • W G Yasmineh
  • R B Pyle
  • D M Nicoloff
چکیده

We determined the decay constant and distribution space of the MB isoenzyme of creatine kinase after intravenous injection of 440 to 720 U, in a group of seven adult baboons. The rate of decay of the isoenzyme was monoexponential, with a mean decay constant of 0.00175 min-1 (SD, 0.00019). The mean distribution volume obtained by extrapolation of the monoexponential curve to zero time was 5.22% (SD, 1.06) of body weight. We have determined these parameters with the purpose of using this isoenzyme in the baboon as an experimental model for measuring myocardial infarct size.

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عنوان ژورنال:
  • Clinical chemistry

دوره 22 7  شماره 

صفحات  -

تاریخ انتشار 1976